Connectomics! Neural Structure Reconstruction from Fluorescence Imaging of Neural Activity
Course Project CS 365A
Karan Singh, Pankaj Gupta
Indian Institute of Technology, Kanpur.
Not so FAQs!
- What are you folks trying to accomplish?
We are trying to figure out pairs of neurons are connected (through a directed edge) from the time series activity of the neurons.
- Why should I be excited about it?
- Understanding the topology underlying neural connections could unravel the cure of neuro-pathologies like epilepsy, Alzheimer's disease.
- It would also lead to a better understanding of how the barin functions in general.
- The task involved inferring statistical causality from time-series data, which is an exciting topic in itself.
- To see why the causality is interesting, go through the comic strips below. First two are from xkcd and the third (at the bottom) from SMBC.
- So, how do you do it?
We look at what different measures of statistical causality and information-theoretic measures have to say about the problem.
We also make a few intersting observation about biological neural networks.
- What's up with such a big title?
The task is to predict the existence of edges; and the neural activity is measured through some abra-kadabra spell -- fluorescence imaging.
- Your work is boring as hell! I don't care!
We are sorry. The title reads "Not so Frequently Asked Questions!" And, this isn't one.
Resources:
Proposal
Slides
Poster
Report
Code